The Effects of Dental Amalgam Toxicity on Health and Nutritional status

Louay M Labban, Mahmoud M Alshishkli, Ahmad Alkhalaf, Zeina Malek

Abstract


Amalgam is a combination of metals that has been the most popular and effective filling material used in dentistry for the last 150 years. Although it sometimes is called “silver amalgam,” amalgam actually consists of a combination of metals. These include silver, mercury, tin and copper. Small amounts of zinc, indium or palladium also may be used.

However, its popularity as restorative material is decreasing nowadays due to concerns about unfavorable health effects and environmental pollution. Researchers agree that amalgam restorations leach mercury into the mouth, but consistent findings are not available to report whether it has any significant health risk. The American Society of Dental Surgeons (ASDS) in the year 1843, declared use of amalgam to be malpractice because of the fear of mercury poisoning in patients. In 1859, the American Dental Association (ADA) was founded and it did not forbid use of amalgam. The ADA position on the safety of amalgam has remained consistent since its foundation. In 1920s inferences were made that mercury was not tightly bound in amalgam so its use was discouraged. In this review, we will show the convincing evidences pointed out to adverse health effects due to dental amalgam restorations.


Keywords


Amalgam, Composites, Toxicity, Multiple sclerosis, Creatinine, Renal function, Hypersensitivity

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References


Dunne SM, Grainsford ID, Wilson NH. Current

materials and techniques for direct restorations in

posterior teeth. Part 1: Silver amalgam. Int Dent

J. 1997;47:123–36.

Hahn LJ, Kloiber R, Leininger RW, Vimy MJ, Lorscheider

FL. Whole-body imaging of the distribution of mercury

released from dental fillings into monkey tissues. FASEB

J. 1990;4:3256–60.

Takahashi Y, Tsuruta S, Arimoto M, Tanaka H, Yoshida

M. Placental transfer of mercury in pregnant rats

which received dental amalgam rstorations. Toxicology.

;185:23–33.

Brownawell AM, Berent S, Brent RL, Bruckner JV, Doull J,

Gershwin EM, Hood RD, Matanoski GM, Rubin R, Weiss

B, Karol MH. The potential adverse health effects of

dental amalgam.Toxicol Rev 2005; 24(1):1-10.

Brune D, Gjerdet N, Paulsen G. Gastrointestinal and

in vitro release of copper, cadmium, indium, mercury

and zinc from conventional and copper-rich amalgams.

Scand J Dent Res 1983;91:66–71.

Berglund A. Estimation by a 24-hour study of the daily

dose of intra-oral mercury vapour inhaled after release

from dental amalgam. J Dent Res 1990;69:1646–51.

Berdouses E, Vaidyanathan TK, Dastane A, Weisel

C, Houpt M, Shey Z. Mercury release from dental

amalgams: an in vitro study under controlled chewing

and brushing in an artificial mouth. J Dent Res

;74:1185–93.

Mackert JR Jr1, Berglund A. Mercury exposure from

dental amalgam fillings: absorbed dose and the

potential for adverse health effects. Crit Rev Oral Biol

Med 1997;8(4):410-36.

Morton J, Mason HJ, Ritchie KA, White M. Comparison

of hair, nails and urine for biological monitoring of low

level inorganic mercury exposure in dental workers.

Biomarkers. 2004;9:47–55.

Daniels JL, Rowland AS, Longnecker MP, Crawford P,

Golding J ALSPAC Study Team. Maternal dental history,

child’s birth outcome and early cognitive development.

Paediatr Perinat Epidemiol 2007;21:448–57.

Spencer AJ .Dental amalgam and mercury in dentistry.

Aust Dent J 2000 Dec;45(4):224-34

Bellinger DC, Trachtenberg F, Barregard L, Tavares

M, Cernichiari E, Daniel D, et al. Neuropsychological

and renal effects of dental amalgam in children: a

randomized clinical trial. JAMA. 2006;295:1775–83.

Lauterbach M, Martins IP, Castro-Caldas A, Bernardo

M, Luis H, Amaral H, et al. Neurological outcomes in

children with and without amalgam-related mercury

exposure: seven years of longitudinal observations in

a randomized trial. J Am Dent Assoc 2008;139:138–45.

Woods JS, Martin MD, Leroux BG, DeRouen TA, Leitão

JG, Bernardo MF, et al. The contribution of dental

amalgam to urinary mercury excretion in children.

Environ Health Perspect 2007;115:1527–31.

Dunn JE, Trachtenberg FL, Barregard L, Bellinger D,

McKinlay S. Scalp hair and urine mercury content

of children in the Northeast United States: the

New England Children’s Amalgam Trial. Environ Res

;107:79–88.

Bates MN, Fawcett J, Garrett N, Cutress T, Kjellstrom

T. Health effects of dental amalgam exposure: a

retrospective cohort study. Int J Epidemiol 2004;33:894–

Aminzadeh KK, Etminan M. Dental amalgam andmultiple sclerosis: a systematic review and metaanalysis.

J Public Health Dent 2007;67:64–6.

Smart ER, McLead RI, Lawrence CM. Resolution of lichen

planus following removal of amalgam restorations in

patients with proven allergy to mercury salts: a pilot

study. Br Dent J 1995;178:108–12.

McCullough MJ, Tyas MJ. Local adverse effects of

amalgam restorations. Int Dent J 2008;58:3–9.

Forte G, Petrucci F, Bocca B. Metal allergens of growing

significance: epidemiology, immunotoxicology,

strategies for testing and prevention. Inflamm Allergy

Drug Targets. 2008;7:145–62. Review.

Bains VK, Loomba K, Loomba A, Bains R. Mercury

sensitisation: review, relevance and a clinical report.

Br Dent J 2008;205:373–8.

Fuks AB. The use of amalgam in pediatric dentistry.

Pediatr Dent 2002;24:448–55.

Sasaki N, Okuda K, Kato T, Kakishima H, Okuma H, Abe

K, et al. Salivary bisphenol-A levels detected by ELISA

after restoration with composite resin. J Mater Sci

Mater Med 2005;16:297–300.

Christensen GJ. Longevity of posterior tooth dental

restorations. J Am Dent Assoc 2005;136:201–3.

Leinfelder KF. Do restorations made of amalgam outlast

those made of resin-based composites? J Am Dent

Assoc 2000;131:1186–7.


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