Analgesic Activity of Sebastiania chamaelea (L.) Muell. Arg.

Anjali Asok, Mahesh C D, Seema Pradeep, Anjana J, Akshatha M Bhat

Abstract


Background: This study intended to experimentally evaluate the analgesic activity of Sebastiania chamaelea (L.) Muell. Arg. which is widely used by folklore and traditional healers in pain relief. The drug is commonly known as ‘Bhumi Eranda’ among the locals.

Methods: The plant material of Sebastiania chamaelea (L.) Muell. Arg. was collected from the fields of Sri Sri College of Ayurvedic Science and Research, Bangalore and preserved as per the standard method. The toxicity studies carried out earlier has proved that, the drug was non-toxic up to 3000 mg/kg body weight. The effective doses were derived as 300 mg/kg (lower) and 600 mg/kg (higher) body weight and the experimental study was conducted. Analgesic screening models used for the study are – Eddy’s Hot plate and Tail immersion models. The study was carried out in 4 groups i.e. Control, Standard, Lower dose Kashaya of Sebastiania chamaelea (L.) Muell. Arg. and Higher dose Kashaya of Sebastiania chamaelea (L.) Muell. Arg. in each model. The activity was compared with a standard reference drug, Tramadol and Diclofenac.

Results: The results were analyzed by using one-way analysis of variance (ANOVA) test followed by Dunnett test to detect the significance of differences between each group and control.

Conclusion: The study helped to conclude, Sebastiania chamaelea (L.) Muell. Arg. as an ideal analgesic and supported the traditional claim.


Keywords


Analgesic, Diclofenac, Tramadol

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