Barrett’s Esophagus: An update

Shubham Haldwani, Rohit Garg, Amit Kumar Yadav


Barrett’s esophagus is premalignant condition in which the stratified squamous epithelium is replaced by metaplastic intestinal epithelium. The cause is usually long-standing gastro-esophageal reflux. Infection with Helicobacter pylori is also believed to play a role in this. The most significant complication is development of dysplasia with an increase in relative risk for development of adenocarcinoma 40–120 times.


Barrett’s esophagus, Metaplasia, Adenocarcinoma

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Spechler SJ, Sharma P, Souza RF et al. American

Gastroenterological Association technical review on

the management of Barrett's esophagus.

Gastroenterology 2011; 140: e18.

Correa P. Helicobacter pylori and gastric

carcinogenesis. Am J Surg Pathol 1995; 19(Suppl 1):


Arditi JD, Venihaki M, Karalis KP et al.

Antiproliferative effect of adiponectin on MCF7

breast cancer cells: a potential hormonal link

between obesity and cancer. Horm Metab Res

; 39: 9.

Parsonnet J. The incidence of Helicobacter pylori

infection. Aliment Pharmacol Ther 1995; 9(Suppl 2):

Ye W, Held M, Lagergren J et al. Helicobacter pylori

infection and gastric atrophy: risk of

adenocarcinoma and squamous-cell carcinoma of

the esophagus and adenocarcinoma of the gastric

cardia. J Natl Cancer Inst 2004; 96: 388.

Vicari JJ, Peek RM, Falk GW et al. The

seroprevalence of cagA-positive Helicobacter pylori

strains in the spectrum of gastroesophageal reflux

disease. Gastroenterology 1998; 115: 50.

Delaney B, McColl K. Helicobacter pylori and

gastro-esophageal reflux disease. Aliment

Pharmacol Ther 2005; 22(Suppl 1): 32.

Wang KK, Sampliner RE. Practice Parameters

Committee of the American College of

Gastroenterology. Updated guidelines 2008 for the

diagnosis, surveillance and therapy of Barrett's

esophagus. Am J Gastroenterol 2008; 103: 788.

Hassall E. Esophageal metaplasia: definition and

prevalence in childhood. Gastrointest Endosc 2006;

: 676.

El-Serag HB, Gilger MA, Shub MD et al. The

prevalence of suspected Barrett’s esophagus in

children and adolescents: a multicenter endoscopic

study. Gastrointest Endosc 2006; 64: 671.

Rec. Adv. Path. Lab. Med. 2017; 3(2) Haldwani S et al.

ISSN: 2454-8642

Spechler SJ, Jain SK, Tendler DA et al. Racial

differences in the frequency of symptoms and

complications of gastro-esophageal reflux disease.

Aliment Pharmacol Ther 2002; 16: 1795.

Wang A, Mattek NC, Holub JL et al. Prevalence of

complicated gastroesophageal reflux disease and

Barrett’s esophagus among racial groups in a

multi-center consortium. Dig Dis Sci 2009; 54: 964.

Lagergren J. Influence of obesity on the risk of

esophageal disorders. Nat Rev Gastroenterol

Hepatol 2011; 8: 340.

Cook MB, Shaheen NJ, Anderson LA et al. Cigarette

smoking increases risk of Barrett’s esophagus: an

analysis of the Barrett’s and esophageal

adenocarcinoma consortium. Gastroenterology

; 142: 744.

Spechler SJ. Are we underestimating acid reflux?

Gut 2004; 53: 162.

Spechler SJ. Barrett esophagus and risk of

esophageal cancer: a clinical review. JAMA 2013;

: 627.

Pohl H, Sirovich B, Welch HG. Esophageal

adenocarcinoma incidence: are we reaching the

peak? Cancer Epidemiol Biomarkers Prev 2010; 19:

Lagergren J, Lagergren P. Recent developments in

esophageal adenocarcinoma. CA Cancer J Clin 2013;

: 232.

Spechler SJ. Intestinal metaplasia at the

gastroesophageal junction. Gastroenterology 2004;

: 567.

Cameron AJ. Epidemiology of columnar-lined

esophagus and adenocarcinoma. Gastroenterol Clin

N Am 1997; 26: 487.

Iftikhar SY, James PD, Steele RJ et al. Length of

Barrett's esophagus: an important factor in the

development of dysplasia and adenocarcinoma. Gut

; 33: 1155.

Menke-Pluymers MB, Hop WC, Dees J et al. Risk

factors for the development of an adenocarcinoma

in columnar-lined (Barrett) esophagus. The

Rotterdam Esophageal Tumor Study Group. Cancer

; 72: 1155.

Weston AP, Krmpotich PT, Cherian R et al.

Prospective long-term endoscopic and histological

follow-up of short segment Barrett’s esophagus:

comparison with traditional long segment Barrett’s

esophagus. Am J Gastroenterol 1997; 92: 407.

Zaninotto G, DeMeester TR, Bremner CG et al.

Esophageal function in patients with reflux-induced

strictures and its relevance to surgical treatment.

Ann Thorac Surg 1989; 47: 362.

Kahrilas PJ, McColl K, Fox M et al. The acid pocket: a

target for treatment in reflux disease? Am J

Gastroenterol 2013; 108: 1058.

Fletcher J, Wirz A, Henry E et al. Studies of acid

exposure immediately above the gastro-esophageal

junction: evidence of short segment reflux. Gut

; 53: 168.

Pandolfino JE, Lee TJ, Schreiner MA et al.

Comparison of esophageal acid exposure at 1 cm

and 6 cm above the squamocolumnar junction using

the Bravo pH monitoring system. Dis Esophagus

; 19: 177.

Iijima K, Henry E, Moriya A et al. Dietary nitrate

generates potentially mutagenic concentrations of

nitric oxide at the gastroesophageal junction.

Gastroenterology 2002; 122: 1248.

Jankowski JA, Wright NA, Meltzer SJ et al. Molecular

evolution of the metaplasia-dysplasia-adenocar

cinoma sequence in the esophagus. Am J Pathol

; 154: 965.

McClave SA, Boyce HW Jr, Gottfried MR. Early

diagnosis of columnar-lined esophagus: a new

endoscopic criterion. Gastrointest Endosc 1987; 33:

Spechler SJ. The columnar lined esophagus: a riddle

wrapped in a mystery inside an enigma. Gut 1997;

: 710.

Sharma P, Morales TG, Sampliner RE. Short segment

Barrett’s esophagus. The need for standardization

of the definition and of endoscopic criteria. Am J

Gastroenterol 1998; 93: 1033.

Sharma P, Dent J, Armstrong D et al. The

development and validation of an endoscopic

grading system for Barrett’s esophagus: the Prague

C & M Criteria. Gastroenterology 2006; 131: 1392.

Choi do W, Oh SN, Baek SJ et al. Endoscopically

observed lower esophageal capillary patterns.

Korean J Intern Med 2002; 17: 245.

Spechler SJ, Zeroogian JM, Antonioli DA et al.

Prevalence of metaplasia at the gastro-esophageal

junction. Lancet 1994; 344: 1533.

Spechler SJ, Sharma P et al. American

Gastroenterological Association medical position

statement on the management of Barrett’s

esophagus. Gastroenterology 2011; 140: 1084.


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