Effect of Drotaverine Hydrochloride on Total Duration of Labor in Primigravida and Multigravida

Sonali Sandeep Gaikwad, Dr. Ammbalal Narayan Gurram


Active management of labor is the demand of modern obstetrics. Attempts to accelerate labor and there by shorten its duration without jeopardizing maternal and fetal outcome are welcome by both patient and obstetrician. In the current study, attempt has been made to find out the various aspects of the use of Drotaverine to fasten delivery and its effect on labor process in primigravida and multigravida. This study was done on 100 pregnant women at term in spontaneous labor. Both primigravida and multigravida were administered injection Drotaverine HCL 40 mg IM at 3- 4cm in early labor, repeated if required maximum up to 3 injections. The duration of 1st stage of labor was calculated. Mode of delivery (spontaneous vaginal, forceps or ventouse) was noted. LSCS was done for appropriate indications but were excluded from study. Also Injection- delivery interval was noted. Number of injections required was also noted. The use of injection Drotaverine HCL in early labor causes significant shortening of duration of dilatation phase of labor, especially primigravida. It probably reduces incidence of cervical tears associated with delivery. Its use in shortening the labor in appropriate doses was found safe for mother and fetus/ neonate.


1st stage of labor, augmentation of labor, Drotaverine Hydrochloride.

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Arulkumaran S, Ratnum SS: The Management of Labor, 1st edition, 1999; 5-6.

Friedman EA, Labor: Clinical evaluation and management, 2nd Edition, Appleton-Century-Crofts 1978.

Cunningham FG, Gant NF, Levenok J, Clinical course of labor, 21st Edition, Williams Obstetrics 2001:252-253.

Turi-Blasko S, Demeter J, The effect of IM drotaverine on the dilatation stage of labor in uncomplicated deliveries. Obstet Gynecol Today, 1998; 3:723-726.

Uldberg N, Ekman G, Malmstorm A et al., Ripening of the human uterine cervix related to changes in collagen, AM J Obstet Gynecol 1983; 147: 662-666.

Tripathi K, Opioid Analgesics and antagonists- Essentials of medical pharmacology 3rd Edition, 388-389.

Beavo JA, Reifsnyder DH, Primary Sequence of cyclic nucleotide phosphodiesterase isoenzymes and design of selective inhibitors, Trends Pharmacol Sci 1990; 11: 150-155.

Suranyi S, Use of spasmolytic agent drotaverine for assistance of labor, Medicus Univ 1972; 22: 202-11.

Sarkar M, Goswamy BL, A study of drotaverine on duration on 1st stage of labor, J Internat Med Sci Acad 2000; 13(4): 256-257.

Mishra SL, Toshiwani A, Banerjee R, Effect of drotaverine on cervical dilatation- a comparative study with epidosin (valethamate bromide), J Obstet Gynecol India 2002; 52(3): 76-79.

Sharma JB, Pundir PK, Murthy NS, Drotaverine HCL Vs Valethamate bromide in acceleration of labor, Int J Gynecol Obstet 2001; 74: 255-260.

Singh KC, Jain P, Goel N et al., Drotaverine HCl for augmentation of labor, IntJ Gynecol Obstet 2004; 84(1): 17-22.

Ranka PR, Hishikar VA, Effect of drotaverine HCL on normal labor –A randomized study, J Obstet Gynecol Ind 2002; 52(6): 28-30.

Kaur D, Kaur R, Comparision of drotaverine and epidosin in 1st stage of labor, J Obstet Gynecol Ind 2003; 53(5): 449-452.

Khosla AH, Bala I, A comparative study of efficacy of valethamate bromide with drotaverine HCL in normal labor, J Obstet Gynecol Ind 2003; 53(6): 568-570.


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