Antenatal Bartter Syndrome: A Rare Case Report with Successful Management

Anita Yadav, Arti Maria, N.K. Dubey, Arushi Verma


Bartter Syndrome (BS) is a rare renal tubular disorder. Of allthe forms, the antenatal form is associated with the worst clinical outcome. A case of antenatal BS is discussed to illustrate that diagnosis in early neonatal period through a meticulous step-wise approachleading to timely initiation of treatment is possible. Extensive review suggests a possibility of diagnosis in antenatal period by simple biochemical analysis of amniotic fluid with implications to further improve perinatal outcomes.


Antenatal Bartter Syndrome, dehydration, hyponatremia, hpokalemia, hypochloremia, metabolic alkalosis

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Seyberth HW. An improved terminology and classification of Bartter-like syndromes, Nat ClinPractNephrol2008; 4(10):560-7.

Bhamkar RP, Gajendragadkar A. Antenatal Bartter's syndrome with sensorineural deafness,Indian J Nephrol 2009; 19(1):23-6.

Bartter FC, Pronove P, Gill JRJr et al. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome.Am J Med 1962; 33:811–28.

Abdel-al YK, Badawi MH, Yaeesh SA et al. Bartter's syndrome in Arabic children: review of 13 cases,PediatrInt 1999; 41(3): 299-303.

Peters M, Jeck N, Reinalter S et al. Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies,Am J Med 2002; 112:183-90.

Magann EF, Chauhan SP, Doherty DA et al. A review of idiopathic hydramnios and pregnancy outcomes,ObstetGynecolSurv 2007; 62(12):795–802.

Dane B, Yayla M, Dane C et al. Prenatal diagnosis of Bartter syndrome with biochemical examination of amniotic fluid: case report,Fetal DiagnTher2007;22 (3): 206–8.

Garnier A, Dreux S, Vargas-Poussou R et al. Bartter syndrome prenatal diagnosis based on amniotic fluid biochemical analysis. Pediatric Research 2010; 67(3): 300-303.

Bhat YR, Vinayaka G, Sreelakshmi K.Antenatal bartter syndrome: a review.Int J Pediatr 2012;857136. doi: 10.1155/2012/857136. Epub 2012 Feb 28.

Dillon MJ, Shah V, Mitchell MD. Bartter syndrome: 10 cases in childhood. Results of long-term indomethacin therapy. Q J Med 1979; 48(191):429-46.


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