Characterization of Tuberculosis positive and negative HIV patients registered at ART Center of C. R. Gardi Hospital Ujjain, M.P.

Tarique Ibrahim, Rashmi Bhujade, B. N. Mishra, Abhinav Sinha, B. L. Bamboriya

Abstract


Introduction: HIV/ AIDS pandemic has caused a resurgence of TB, resulting in increased morbidity and mortality worldwide. HIV and Mycobacterium tuberculosis have a synergistic interaction; each accentuates progression of the other. Clinical presentation of TB in early HIV infection resembles that observed in immunocompetent persons.

Objective:

  • To assess the socio-demographic profile and prevalence of pulmonary tuberculosis among HIV positive patients.
  • To assess the clinical status in terms of their CD4 count, weight, hemoglobin percentage and WHO clinical stage.

Materials and Methods: A record based study of HIV patients registered at ART center of C. R. Gardi Hospital was studied. A total of 147 patients were studied who were registered during January 2009 to December 2010 at ART center. These 147 patients’ records were separated into two groups i.e. HIV with Tuberculosis (61) and HIV without Tuberculosis (86). Data were recorded from NACO patient’s card and were analyzed.

Conclusion: The prevalence of TB in HIV patients was found to be 41%. Many sociodemographic variables show significant association with HIV TB Co- infection. Difference in CD4 count, weight, Hb%, and WHO stage was also observed in HIV TB co- infection and only HIV patients. All HIV- infected individuals should be tested for tuberculosis prior to the initiation of ART in countries like India where tuberculosis is endemic.


Keywords


HIV, TB, CD4, WHO stage.

Full Text:

PDF

References


Corbett EL, Watt CJ, Walker N et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 2003; 163: 1009–21.

Servilio J. HIV/TB dual infection cause for concern. Posit Aware 1995; 8.

Harries A, Dye C. Tuberculosis. Annals of Tropical Medicine and Parasitology 2006; 100(5): 415-31.

Reid A, Scano F, Getahun H et al. Towards universal access to HIV prevention, treatment, care, and support: the role of tuberculosis/HIV collaboration. Lancet Infect Dis 2006; 6(8): 483-95.

Elzinga G, Raviglione MC, Maher D. Scale up: meeting targets in global tuberculosis control. Lancet 2004; 363: 814–19.

World Health Organization. Towards universal access scaling up priority HIV/AIDS interventions in the health sector. Progress report 2008. Geneva: World Health Organization, United Nations Joint Programme on HIV/AIDS, 2008.

Stop-TB-Partnership. The Global Plan to Stop TB (2006–2015). Geneva: World Health Organization, 2006.

Vidyanathan PS, Singh S. TB-HIV co-infection in India. NTI Bull 2003; 39: 11–15.

Jain SK, Aggarwal JK, Rajpal S et al. Prevalence of HIV infection among tuberculosis patients in Delhi-A sentinel surveillance study. Indian J Tuberc 2000; 47: 21-26.

Stylblo K. The global aspects of tuberculosis and HIV infection. Bull Int Union Tuberc Lung Dis 1990; 65: 28–32.

Escott S, Nsuteby E, Walley J et al. Management of TB in countries with high HIV prevalence. Afr Health 2001; 23: 12–15.

DeCock KM, Sero B, Coulibaly IM et al. Tuberculosis and HIV infection is Sub-Sahara Africa. JAMA 1992; 278: 1581–87.

Enarson DA, Rieder HL, Arnadottir T et al. Management of tuberculosis, a guide for low income Countries. 5th ed. Paris. International union against tuberculosis and lung disease (IUATLD) Tuberculosis and HIV, 2000: 10–53.

Shafer RW. Tuberculosis. In: Textbook of AIDS medicine. Broder S, Merigan TC Jr, Bolognesi D (editors). 2nd ed. Baltimore: Williams and Wilkins, 1994: 259–82.

Festenstein F, Grange JM. Tuberculosis and the acquired immune deficiency syndrome. J Appl Bacteriol 1991; 71: 19–30.

Chakravarty J, Mehta H, Parekh A et al. Study on Clinico-epidemiological Profile of HIV Patients in Eastern India. JAPI Nov 2006; 54.

Narain JP, Pontali E, Tripathy S. Sentinel surveillance for HIV infection in tuberculosis patients in India. Indian J Tuberc 2002; 49: 17–20.

Khatri GR, Frieden TR. Controlling tuberculosis in India. N Eng J Med 2003; 347: 1420–25.

Kaiser Weekly TB/Malaria Report. HIV/TB co-epidemic rapidly is spreading in sub-Saharan Africa. Available from: http://www. globalhealth.kff.org/Daily-Reports/ 2007/ 02/ dr00048620aspx. Accessed on: November 2, 2011.

Sharma SK, Agarwal G, Seth P et al. Increasing seropositivity among adult tuberculosis patients in Delhi. Indian J Med Res 2003; 117: 239–42.

Kebede A, Wabe NT. Medication adherence and its determinants among patients on concomitant tuberculosis and antiretroviral therapy in South West Ethiopia. N Am J Med Sci 2012; 4: 67–71.

Nissapatorn V, Christopher L, Init I et al. Tuberculosis in AIDS Patients. Malays Med Sci 2003; 10: 60–64.

Toossi Z. Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease. J Infect Dis 2003; 188: 1146-55.

Whalen C, Horsburgh CR, Hom D et al. Accelerated course of human immunodeficiency virus infection after tuberculosis. Am J Respir Crit Care Med 1995; 151: 129-35.

Vanham G, Edmonds K, Qing L et al. Generalized immune activation in pulmonary tuberculosis: co-activation with HIV infection. Clin Exp Immunol 1996; 103: 30-34.

World Health Organization. Tuberculosis facts. 2007. Available from: http://www.cdc.gov/ hiv/resources/factsheets/hivtb.htm. Accessed on: January 10, 2012.


Refbacks

  • There are currently no refbacks.


Copyright (c)