Pancytopenia in Cytophagic Histiocytic Panniculitis - Case Report

Ritin Mohindra, Santosh Ghai, Narender Singh Negi, Neelima Jain


Cytophagic histiocytic panniculitis (CHP) is a rare subtype of panniculitis that usually follows a fatal course, with a terminal hemophagocytic syndrome. We observed a case of pancytopenia, generalized lymphadenopathy and panniculitis, which on subsequent investigations (skin biopsy and bone marrow biopsy) revealed hemophagocytic and cytophagocytic picture.


Pancytopenia, Panniculitis

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Winkelmann RK, Bowie EJ. Hemorrhagic diathesis associated with benign histiocytic, cytophagic panniculitis and systemic histiocytosis. Arch Intern Med Nov 1980; 140(11):1460-63. 2. Aronson IK, Worobec SM. Cytophagic histiocytic panniculitis and hemophagocytic lymphohistiocy tosis: An overview. Dermatol Ther Aug 2010; 23(4): 389-402. 3. Crotty CP, Winkelmann RK. Cytophagic histiocytic panniculitis with fever, cytopenia, liver failure, and terminal hemorrhagic diathesis. J Am Acad Dermatol Feb 1981; 4(2): 181-94. 4. Marzano AV, Berti E, Paulli M et al. Cytophagic histiocytic panniculitis and subcutaneous panniculitis-like T-cell lymphoma: report of 7 cases. Arch Dermatol Jul 2000; 136(7): 889-96. 5. Manoj J, Kaliyadan F, Unni M et al. Cytophagic Histiocytic Panniculitis: Report of Two Cases. Indian J Dermatol 2011; 56(3): 306-308.

J. Adv. Res. Med. 2016; 3(2&3) Mohindra R et al.

ISSN: 2349-7181

Weitzman S. Approach to hemophagocytic syndromes. ASH Educ Program Book Dec 2011; 2011(1): 178-83. 7. Janka GE. Hemophagocytic syndromes. Blood Rev Sep 2007; 21(5): 245-53. 8. Gonzales CL, Medeiros J, Braziel RM et al. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol 1991: 1517-27. 9. Barron DR, Davis BR, Pomeranz JR et al. Cytophagic histiocytic panniculitis: a variant of malignant histiocytosis. Cancer 1985; 55: 2538-42. 10. White Jr JW, Winkelmann RK. Cytophagic histiocytic panniculitis is not always fatal. J Cutan Pathol 1989; 16: 137-44. 11. Von den Driesch P, Staib G, Simon J et al. Subcutaneous T-cell lymphoma. J Am Acad

Dermatol Feb 1997; 36(2): 285-89. 12. Ostrov BE, Athreya BH, Eichenfield AH et al. Successful treatment of severe cytophagic histiocytic panniculitis with cyclosporine A. Semin Arthritis Rheum Jun 1996; 25(6): 404-13. 13. Ito M, Ohira H, Miyata M et al. Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment. Intern Med Tokyo Jpn Mar 1999; 38(3): 296-301. 14. Koizumi K, Sawada K, Nishio M et al. Effective highdose chemotherapy followed by autologous peripheral blood stem cell transplantation in a patient with the aggressive form of cytophagic histiocytic panniculitis. Bone Marrow Transplant Jul 1997; 20(2): 171-73.


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