Recurrent Malignant Phyllodes Tumor of the Breast: A Rare Occurrence in a Young Nulliparous Woman

Shipra Singhal, Sonam Sharma, Rajat Kamra, Rachit Sharma

Abstract


Phyllodes tumor of the breast is an uncommon fibroepithelial neoplasm and accounts for less than 1% of the primary breast neoplasms. The median age of its occurrence is 40–50 years. It has been sub classified histologically as benign, borderline or malignant. Accurate preoperative diagnosis and proper management are crucial for this tumor as it has a high potential for recurrence. The diagnosis of this rare tumor is based on clinical examination, radiology and cytology, but it is the histopathology which is the gold standard for it. Surgery is the treatment of choice, whereas chemotherapy, radiotherapy and hormonal therapy have got limited role so far. We report a rare case of recurrent malignant phyllodes tumor in a young nulliparous female, which is not the usual age group for this tumor.


Keywords


Phyllodes tumor, Malignant, Nulliparous, Recurrence

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References


Gunasekaran G, Naik D, Sharma S et al. Recurrent

phyllodes tumor of breast transforming to a

fibrosarcoma. Int Surg J. 2014; 1(3): 173-36.

Sharma S, Rana BP. Giant fibroadenoma of breast:

A diagnostic dilemma in a middle aged woman. Adv

Cytol Pathol. 2017; 2(4): 00029.

Bhasin SK, Kumari S, Kumar V et al. Bilateral benign

giant phyllodes tumor in an adolescent female: A rare

case report. Int Surg J. 2014; 1(3): 177-80.

Grabowski J, Salzsrein SL, Sadler GR et al. Malignant

phyllodes tumors: A review of 752 cases. Am Surg.

; 73(10): 967-69.

Nayak M, Patra S, Mishra P et al. Malignant

phyllodes tumor with heterologous differentiation:

Clinicopathological spectrum of nine cases in a tertiary

care institute in Eastern India. Indian J Pathol Microbiol

; 60(3): 371-76.

Bernstein L, Deapen D, Ross RK. The descriptive

epidemiology of malignant cystosarcoma phyllodes

tumors of the breast. Cancer. 1993; 71(10): 3020-24.

Reinfuss M, Mitus J, Duda K et al. The treatment and

prognosis of patients with phyllodes tumor of the

breast: an analysis of 170 cases. Cancer 1996; 77(5):

-16.

Ahmad Z, Koshariya M, Shukla S et al. A rare case of

recurrent malignant phyllodes tumor of the breast in

a young nulliparous woman. Clin Cancer Investig J.

; 3:173-75.

Kapiris I, Nasiri M, A’Hern R et al. Outcome and

predictive factors of local recurrence and distance

metastases following primary surgical treatment of

high-grade malignant phyllodes tumors of the breast.

Eur J Surg Oncol. 2001; 27(8): 723-30.

Barth RJ Jr. Histological features predict local recurrence

after breast conserving therapy of phyllodes tumors.

Breast Cancer Res Treat. 1999; 57(3): 291-95.

Sharma S, Chintamani, Khambra P et al. Synchronous

oral and breast malignancies: A rare presentation.

Indian J Surg Oncol. 2017; 8(3): 426-29.

Muller J. Uber den feineran Bau und die Forman der

krankhaften Geschwilste. 1838; 1: 54-7.

Sani M, Leow V, Zaidi Z et al. Malignant phyllodes

tumour: A case report. The Internet Journal of Surgery

; 21(2).

Holthouse DJ, Smith PA, Naunton-Morgan R et al.

Cystosarcoma phyllodes: The Western Australian

experience. Aust N Z J Surg 1999; 69(9): 635-38.

Kok K, Telesinghe PU, Yapp SK. Treatment and outcome

of cystosarcoma phyllodes in Brunei: A 13-year

experience. J R Coll Surg Edinb. 2001; 46(4): 198-201.

Liberman L, Bonaccio E, Hamele-Bena D et al. Benign

and malignant phyllodes tumors: Mammographic and

sonographic findings. Radiology 1996; 198(1): 121-24.

Sharma S, Singhal S, Sharma R. Cysticercosis of breast

masquerading as fibroadenoma. Rec Adv Path Lab

Med. 2016; 2(2): 7-9.

Noguchi S, Aihara T, Motomura K et al. Demonstration

of polyclonal origin of giant fibroadenoma of the breast.

Virchows Arch. 1995; 427(3): 343-47.

Barnes L, Pietruszka M. Rhabdomyosarcoma arising

within a cystosarcoma phyllodes. Case report and

review of the literature. Am J Surg Pathol. 1978; 2:

-29.

Grimes MM. Cystosarcoma phyllodes of the breast:

Histologic features, flow cytometric analysis, and

clinical correlations. Mod Pathol.1992; 5(3): 232-39.

Rowell MD, Perry RR, Hsiu JG et al. Phyllodes tumors.

Am J Surg. 1993; 165(3): 376-79.

Pandy M, Matthew A, Jayabreek I et al. Malignant

phyllodes tumor. Breast J. 2001; 7(6): 411-16.

Ramakant P, Chakravarthy S, Cherian JA et al. Challenges

in management of phyllodes tumors of the breast: A

retrospective analysis of 150 patients. Indian J Cancer

; 50(4): 345-48.

Lenhard MS, Kahlert S, Himsl I et al. Phyllodes tumour

of the breast: clinical follow-up of 33 cases of this

rare disease. Eur J Obstet Gynecol Reprod Biol. 2008;

(2): 217-21.

Reinfuss M, Mitus J, Smolak K et al. Malignant phyllodes

tumours of the breast. A clinical and pathological

analysis of 55 cases. Eur J Cancer 1993; 29A(9): 1252-56.

Pietruszka M, Barnes L. Cystosarcoma phyllodes: A

clinicopathologic analysis of 42 cases. Cancer 1978;

(5): 1974-83.

Joshi SC, Sharma DN, Bahadur AK et al. Cystosarcoma

phyllodes: Our institutional experience. Australas

Radiol. 2003; 47(4): 434-37.

Chaney AW, Pollack A, McNeese MD et al. Adjuvant

radiotherapy for phyllodes tumor of breast. Radiat

Oncol Investig. 1998; 6(6): 264-67.

Barrow BJ, Janjan NA, Gutman H et al. Role of

radiotherapy in sarcoma of the breast – A retrospective

review of the M.D. Anderson experience. Radiother

Oncol. 1999; 52: 173-78.

Testori A, Meroni S, Errico V et al. Huge malignant

phyllodes breast tumor: a real entity in a new era of

early breast cancer. World J Surg Oncol. 2015; 13: 81.


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