Effect of Lakshadigana Taila on Wound Healing in Albino Rat

Pushpa Gond, Santosh Kumar Singh, Ragini Tilak, Lakshman Singh

Abstract


Objective: To investigate the wound-healing potency of the Lakshadigana Taila on the excisional wound
healing process in experimental study of albino rats, in comparison to 5% Povidone Iodine solution and
untreated group.
Materials and Methods: Albino rats of either sex weighing between 200 and 300 gm were divided randomly
into three groups (n=6). The animals were anesthetized with anesthetic agent Thiopentone Sodium 25
mg/kg intra peritoneal. The skin of albino rats was saved on one side of paravertebral region. The skin
was disinfected using cotton and alcohol wipes. Excisional wound, full thickness skin wounds of diameter
10 mm were created in the paravertebral area. The following medications were applied topically to the
wound once daily for a maximum of 16 days. In Group I (trial group) Lakshadigana Taila was applied on
rats, in Group II (positive control), 5% Povidone Iodine solution was applied on rats and Group III (negative
control) served as untreated. Wound was measured on days 0, 4, 8, 12 and 16 of the experiment and
histopathological of H and E stain study done on day 4 and 8, 12 and 16. Statistical analysis was done
using analysis of One Way ANOVA followed by Post Hoc Test and P <0.05 was considered significant and
<0.001 highly significant.
Result: Area of wound was measured in all three groups at different intervals and found that the rate of
wound contraction was statistically highly significant in all groups (p <0.001). Rate of wound contraction
was faster in Group I than in Group II and III.
Conclusion: In the present study, topical application of Lakshadigan Taila accelerated healing of excisional
wound in albino rats.


Keywords


Lakshadigana Taila, Wound healing

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