Treatment of warts by Topical retinoids: An Exploration and meticulosity

Ruchi Tiwari, Gaurav Tiwari, Pranay Wal, Ankita Wal

Abstract


Warts are clinically skin infections caused by Human Papilloma Virus (HPV). Some warts are painful while others cause frustration in patients. Warts are contagious and need to be diagnosed clinically from the outgrowth of skin. Topical retinoids have clinical use for treatment of chronic skin conditions. Topical retinoids for treatment of skin cancer are tretinoin, the acid form of vitamin A, also known as all-trans retinoic acid, which is the active vitamin A metabolite in several tissues, isotretinoin (13-cis-retinoic acid), and two third-generation retinoids, adapalene and tazarotene. Vitamin A is necessary for the growth and differentiation of epithelial tissues. Retinoids influence the process of vitamin A by interacting with specific cellular and nuclear receptors of skin. In that way retinoids control cell proliferation and differentiation and potentially interfere with the tumor promotion phase of carcinogenesis by inducing apoptosis. Review of medical literatures from past few years revealed monotherapies and combination therapies to eradicate viral infections caused by HPV. Purpose of this review article is to provide general information about warts,
its mechanism and treatment by topical retinoids.


Keywords


Antiquity of warts, Diagnosis, Topical retinoids and its mechanism of action, Exploration of tretinoin

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