Dengue Sero-surveillance in Delhi: A Community-Based Study

Shantanu Sharma, V K Gupta, Anita Chakravarty, Suneela Garg

Abstract


Background: IgG ELISA is useful as an epidemiological tool when used to establish sero-prevalence. Extensive background information is required before selecting sites for dengue vaccine trials like types of dengue virus that are causing disease, preferably over a number of years, sero-prevalence of dengue
IgG antibodies, prevalence of each serotype, rates of infection, specific mortality, etc.

Aims and Objectives
• To study the prevalence of dengue IgG antibodies in the serum of adults in urban slums of Delhi
• To study the knowledge, attitude and the practice of study subjects about the prevention of mosquito breeding and dengue fever

Methodology: This cross-sectional study was conducted from January 2013 to December 2013 in two urban slums of Delhi, Balmiki Basti and Delhi Gate. All adults aged 20 years and above were included in the study irrespective of sex and previous history of dengue. Knowledge, attitude and practices against
mosquito breeding were also taken through predesigned, pretested questionnaires.

Results: A total of 49(20.5%) adults from Balmiki Basti and 190 from Delhi Gate were enrolled in the study. Mean IgG dengue OD levels of the study subjects was 1.62±0.568. Of the total, 86% were positive for dengue IgG positivity while 13% negative and 1% equivocal. Of all participants, 214(89.9%) were aware
of mode of dengue transmission while 25(10.1%) were not. Majority of the participants 137(57.3%) used liquid vaporizers for prevention of mosquito bites.

Discussion: The current study reported that 85.4% of the healthy population in urban slums of Delhi is seropositive for dengue IgG, which indicates the unprecedented extent of exposure to dengue virus. It is 7.8% higher than the study conducted in Delhi in 1998(77.6%). It coincides with the rising trend of dengue cases every year in Delhi, making it an endemic region now.


Keywords


Dengue, Sero-prevalence, IgG antibody, Sero-epidemiology

Full Text:

PDF

References


Thai KTD, Binh TQ, Giao PT et al. Seroprevalence of

dengue antibodies, annual incidence and risk factors

among children in southern Vietnam. Tropical Medicine

and International Health Apr 2005; 10(4): 379-86.

World Health organization. Dengue and dengue

haemorrhagic fever. 2008 [online] 2008 May 20

[factsheet117]; Available from: URL: http://www.who.

int/mediacentre/factsheets/fs117/en/. (accessed Sep

2013).

National Vector Borne Disease Control Programme,

Director General Health Services, Ministry of Health

and Family Welfare (online); Available from: URL:

http://www.nvbdcp.gov.in. (accessed Apr 12, 2014).

Kurukumbi M, Wali JP, Broor S et al. Seroepidemiology

and active surveillance of dengue fever/dengue

haemorrhagic fever in Delhi. Ind J of for Medi Sci 2001;

(3):149-56.

World Health Organization. Guidelines for the clinical

evaluation of dengue vaccines in endemic areas: WHO

Sep 2008.

Tran TN, DeVries PJ, Hoang LP. Enzyme-linked

immunoassay for dengue virus IgM and IgG antibodies

in serum and filter paper blood. BMC Infect Dis. 2006;

: 13.

Halstead SB. Antibody, macrophages, dengue virus

infection, shock, and hemorrhage: a pathogenetic

cascade. Reviews of Infectious Diseases. 1989; 11(Suppl

: 830-39.

Halstead SB, Papaevangelou G. Transmission of dengue

and 2 viruses in Greece in 1928. Am. J. Trop. Med.

Hyg. 1980; 29: 625-37.

Duncombe J, Weinstein P, Aaskov J et al. Seroprevalence

of dengue in American Samoa, 2010. Emerging

Infectious Diseases 2013; 19(2): 324-26.

Ukey PM, Bondade SA, Paunipagar PV et al. Study of

seroprevalence of dengue fever in central India. Indian

Journal of Community Medicine 2010; 35(4): 517-19.

Mahmood S, Nabeel H, Hafeez S et al. Seroprevalence of

dengue IgG antibodies among healthy adult population

in Lahore, Pakistan. ISRN Tropical Medicine 2013: 1-6.

Sultana N, Biswas SK, Sultan T et al. Seroprevalence of

dengue fever in Chittagong, Bangladesh. Chattagram

Maa-O-Shishu Hospital Medical College Journal 2013;

(1): 38-40.

Malavige GN, Fernando S, Aaskov J. Seroprevalence of

anti-dengue virus antibodies in children in Colombo

district, Sri Lanka. Dengue Bulletin 2006; 30: 68-71.

Ha DQ, Huong VTQ, Loan HTK et al. Dengue

haemorrhagic fever in the south of Vietnam during

–1992 and its control strategy. Nagasaki University

Tropical Medicine. 1994; 36: 187-201.

Strickman D, Sithiprasasna R, Kittayapong P et al.

Distribution of dengue and Japanese encephalitis

among children in rural and suburban Thai villages.

American Journal of Tropical Medicine and Hygiene

; 63: 27-35.

Reiskind MH, Baisley KJ, Calampa C. Epidemiological

and ecological characteristics of past dengue virus

infection in Santa Clara, Peru. Tropical Medicine and

International Health 2001; 6: 212-18.

Bartley LM, Carabin H, Vinh CN. Assessment of the

factors associated with flavivirus seroprevalence in a

population in Southern Vietnam. Epidemiology and

Infection 2002; 128: 213-20.

Wilder-Smith A, Foo W, Earnest A et al. Seroepidemiology

of dengue in adult population of Singapore. Tropical

Medicine and International Health 2004; 9: 305-18.

Amarasinghe A, Kuritsky JN, William Letson G et al.

Dengue virus infection in Africa. Emerging Infectious

Diseases 2011; 17(8): 1349-54.

Braga C, Luna CF, Martelli CMT. Seroprevalence and

risk factors for dengue infection in socio-economically

distinct areas of Recife, Brazil. Acta Tropica 2010;

(3): 234-40.

Rigau-Perez JG, Clark GG, Gubler DJ. Dengue and

dengue haemorrhagic fever. Lancet 1998; 352: 971-17.

Vaughn DW, Nisalak A, Solomon T. Rapid serologic

diagnosis of dengue virus infection using a commercial

capture ELISA that distinguishes primary and secondary

infections. American Journal of Tropical Medicine and

Hygiene 1999; 60: 693-18.

Van Benthem BH, Khantikul N, Panart K et al. Knowledge

and use of prevention measures related to dengue in

northern Thailand. Trop Med Int Health 2002; 7(11):

-1000.

Matta S, Khokhar A, Sachdev TR. Assessment of

knowledge about malaria among patients reported

with fever: a hospital-based study. J Vector Borne Dis.

; 41(1-2): 27-31.

Hairi F, Ong CH, Suhaimi A et al. A knowledge, attitude

and practices(KAP) study on dengue among selected

rural communities in the Kuala Kangsar district. Asia

Pac J Public Health 2003; 15(1): 37-43.

Naik PR, Nirgude AS, Prakash GK. Knowledge and

preventive practices regarding dengue among adult

population of rural area of Nalgonda district, South

India. Int J Biol Med Res. 2011; 2(3): 652-55.

Boratne A, Datta S, Singh Z et al. Attitude and

practices regarding mosquito borne diseases and

socio demographic determinants for use of personal

protection methods among adults in coastal

Pondicherry. Ind J Med Specialities 2010; 1(2): 91-96.

Syed M, Saleem T, Syeda UR et al. Knowledge, attitudes

and practices regarding dengue fever among adults of

high and low socioeconomic groups. J Pak Med Assoc.

; 60(3): 243-47.

Pandit N, Patel Y, Bhavsar B. Awareness and practice

about preventive method against mosquito bite in

Gujarat. Healthline 2010; 1(1): 16-20.

Snehlata KS, Ramaiah KD, Kumar V et al. The mosquito

problem and type and cost of personal protection

as a measure used in rural and urban communities

in Pondicherry region, South India. Acta Trop. 2003;

(1): 3-9.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Journal of Communicable Diseases (P-ISSN: 0019-5138)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.